Broken colinearity of the amphioxus Hox cluster
نویسندگان
چکیده
منابع مشابه
The amphioxus Hox cluster: deuterostome posterior flexibility and Hox14.
The amphioxus (Branchiostoma floridae) Hox cluster is a model for the ancestral vertebrate cluster, prior to the hypothesized genome-wide duplications that may have facilitated the evolution of the vertebrate body plan. Here we describe the posterior (5') genes of the amphioxus cluster, and report the isolation of four new homeobox genes. Vertebrates possess 13 types of Hox gene (paralogy group...
متن کاملThe amphioxus Hox cluster: characterization, comparative genomics, and evolution.
The amphioxus Hox cluster is often viewed as "archetypal" for the chordate lineage. Here, we present a descriptive account of the 448 kb region spanning the Hox cluster of the amphioxus Branchiostoma floridae from Hox14 to Hox1. We provide complete coding sequences of all 14 previously described amphioxus sequences and give a detailed analysis of the conserved noncoding regulatory sequence elem...
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The Hox genes are involved in patterning along the A/P axes of animals. The clustered organization of Hox genes is conserved from nematodes to vertebrates. During evolution, the number of Hox genes within the ancestral complex increased, exemplified by the five-fold amplification of the AbdB-related genes, leading to a total number of thirteen paralogs. This was followed by successive duplicati...
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The Hox gene cluster has been a key paradigm for a generation of developmental and evolutionary biologists. Since its discovery in the mid-1980's, the identification, genomic organization, expression, colinearity, and regulation of Hox genes have been immediate targets for study in any new model organism, and metazoan genome projects always refer to the structure of the particular Hox cluster(s...
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During mammalian fetal development, axial structures acquire their specifications through the action of the Hox gene family of transcription factors (for review, see Krumlauf 1994). These are 39 such genes that are responsible for giving spatially restricted cues in a variety of embryonic derivatives, from the neural tube to the intestinal tract. In presomitic mesoderm, for example, level-speci...
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ژورنال
عنوان ژورنال: EvoDevo
سال: 2012
ISSN: 2041-9139
DOI: 10.1186/2041-9139-3-28